PINK1 deficiency in b-cells increases basal insulin secretion and improves glucose tolerance in mice
نویسندگان
چکیده
Emma Deas1, Kaisa Piipari2, Asif Machhada3, Abi Li1, Ana Gutierrez-del-Arroyo4, Dominic J. Withers2, Nicholas W. Wood1 and Andrey Y. Abramov1 Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK Metabolic Signalling Group, Medical Research Council (MRC), Clinical Sciences Centre, Imperial College London, London W12 0NN, UK Department of Neuroscience, Physiology and Pharmacology, UCL, Gower Street, London WC1E 6BT, UK UCL Clinical Physiology, Wolfson Institute for Biomedical Research, Division of Medicine, London WC1E 6BT, UK
منابع مشابه
PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice
The Parkinson's disease (PD) gene, PARK6, encodes the PTEN-induced putative kinase 1 (PINK1) mitochondrial kinase, which provides protection against oxidative stress-induced apoptosis. Given the link between glucose metabolism, mitochondrial function and insulin secretion in β-cells, and the reported association of PD with type 2 diabetes, we investigated the response of PINK1-deficient β-cells...
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